Faculty of Murder is set at Brigid Moore Hall, a girls' hostel in the University of Melbourne, where "freshettes" are shocked by a new arrival, Judith Mornane, who announces that she intends to discover her sister's murderer. Her sister, Maureen, had mysteriously disappeared from the hostel the year before, at about the same time that a professor's wife had accidentally drowned. It is left to the newly arrived Warden, Mother Paul, together with Elizabeth Drew, the Humanities tutor, to draw the police's attention to possibilities they might not have considered.